Recent advances in genomics have significantly revolutionized the ways which we do science in the 21st century. With the completion of the human draft genome, the new genome technologies have transformed our ability to understand the structure and function of genomes and allow scientists to explore the genomes of multicellular organisms. This course is designed to introduce undergraduate students, who are interested in this exciting and rapidly evolving field, the basic knowledge of genome and the state-of-the-art genome technologies. The lectures will cover an introduction on genome projects, sequencing technologies, genetic variation, transcriptomics, proteomics, functional genomics, comparative genomics, metagenomics and epigenomics. This semester, we are part of the Genome Education Partnership (GEP) and students taking this course will work on an annotation project under the guidance of the instructors. The goal is to provide opportunities for undergraduate students to participate in genomic research. Students will learn to annotate genes and other features, leading to analysis of a question in genomics and research publication. More information about GEP can be found at http://gep.wustl.edu and the 2014 project is described at http://gep.wustl.edu/projects/dot_chromosome.